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MGH Division of Clinical Research

A Practical Guide to Biobanking for Biomarker and Personalized Medicine Research

A Practical Guide to Biobanking for Biomarker and Precision Medicine Tuesday, January 9, 2018 1:00pm – 4:00pm, Simches Research Center, Floor 3, Simches 3.110 Presented by MGH Division of Clinical Research, Harvard Catalyst Clinical and Translational Science Center, and the …

MGH Division of Clinical Research

A Practical Introduction to Statistical Genetics- Introduction

Session 1- Sept 4: Introduction Topics: overview of the course Speaker: Tian Ge A Practical Introduction to Statistical Genetics Wednesdays, Sept 4, 11, 18, 25, Oct 2, 9, 23 Nov 6, 13, 20 Simches Research Center, 2nd floor, Garrod/Mendel Conference …

MGH Division of Clinical Research

A Practical Introduction to Statistical Genetics: Heritability and Genetic Correlation Analyses

Session 6- Oct 9: Heritability and genetic correlation analyses Topics: definition of broad-sense/narrow-sense heritability; twin and pedigree studies; SNP heritability; linear mixed effects modeling and GCTA; heritability estimation using GWAS summary statistics – LD score regression; liability model and case-control …

MGH Division of Clinical Research

A Practical Introduction to Statistical Genetics: Polygenic Risk Scores (PRS)

Session 5- Oct 2: Polygenic risk scores (PRS) Topics: polygenic model of complex traits and disease susceptibility; discovery (training), validation and target (testing) samples; calculation of PRS – p-value informed clumping and thresholding; evaluation (performance metrics – variance explained, odds …

MGH Division of Clinical Research

A Practical Introduction to Statistical Genetics: Transcriptome and TWAS

Session 8- Nov 6: Transcriptome and TWAS Topics: non-coding GWAS SNPs; gene expression regulation; tissue-specific expression quantitative trait loci (eQTLs); The Genotype-Tissue Expression (GTEx) Project (tissue types, sample characteristics, data portal, eQTL networks, gene regulatory networks); multi-tissue transcriptome; public eQTL …

MGH Division of Clinical Research

A Practical Introduction to Statistical Genetics: Conducting Genomic Research Using Biobanks

Session 10- Nov 20: Conducting genomic research using biobanks Topics: UK Biobank, eMERGE network and Partners HealthCare Biobank, All of Us Research Program, genetic research using electronic health records (EHR) Speaker: Jordan Smoller

MGH Division of Clinical Research

A Practical Introduction to Statistical Genetics: Genome-Wide Association Studies (I)

Session 2- Sept 11: Genome-wide association studies (I) Topics: GWAS history; genotyping technology; linkage disequilibrium, haplotype and tagging genetic variation; study design and statistical power; population stratification; marker quality control (marker call rate, minor allele frequency, Hardy-Weinberg equilibrium, differential missingness …

MGH Division of Clinical Research

A Practical Introduction to Statistical Genetics: Genome-Wide Association Studies (II)

Session 3- Sept 18: Genome-wide association studies (II) Topics: association analysis (regression, effect size and odds ratio, hypothesis testing, type I and type II errors); visualization and diagnosis (Manhattan plot, LocusZoom, population stratification, spurious association); GWAS summary statistics; meta-analysis; functional …

MGH Division of Clinical Research

A Practical Introduction to Statistical Genetics: Introduction to Sequencing Data Analysis

Session 9- Nov 13: Introduction to sequencing data analysis Topics: next generation sequencing and exome sequencing; common vs. rare variants; alignment and variant calling, filtering and quality control; variant annotation (protein-truncating, damaging missense, benign missense, synonymous); single variant association; gene-based …

MGH Division of Clinical Research

A Practical Introduction to Statistical Genetics: Mendelian Randomization (MR)

Session 7- Oct 23: Mendelian randomization (MR) Topics: causal effects and graphical representation; instrumental variables; basic ideas, advantages, assumptions and caveats of MR; two-stage least square method for MR; ratio of coefficient method for MR; MR using multiple SNPs; MR …

MGH Division of Clinical Research

A Practical Introduction to Statistical Genetics: Statistical Fine-Mapping

Session 4- Sept 25: Statistical fine-mapping Topics: goal of statistical fine-mapping; partitioning and interpreting GWAS lead signals; factors influencing fine-mapping (sample size, number of causal SNPs, effect sizes of causal SNPs, local LD structure, SNP density); statistical methods and software …

MGH Division of Clinical Research

A Primer on Complex Trait Genetics

A Primer on Complex Trait Genetics: Principles for the Beginning Investigator Monday, September 23, 2019, 8:00am – 3:00pm, Simches Room 3.110 This event is sponsored by the MGH Division of Clinical Research. Are you able to keep up with the …

MGH Division of Clinical Research

Next Generation Sequencing: An Introduction and Clinical Applications

This course is intended for investigators and research staff at all levels interested in next-generation sequencing resources and applications. It will include an introductory lecture on next-generation sequencing technology and sample preparation, lectures on how to interpret the data and …

MGH Division of Clinical Research

Responsible Conduct of ‘Omics’ Research

Responsible Conduct of ‘Omics’ Research Sponsored by the Division of Clinical Research at MGH Join us for this exciting course looking at complex challenges that have become widespread due to rapid advances in genomic technologies, large scale data sharing, and …

MGH Division of Clinical Research

The Implementation of Precision Medicine: Integrating Translational Research and Care Redesign

The Implementation of Precision Medicine: Integrating Translational Research and Care Redesign presented by Dr. Calum MacRae, MD, PhD, Chief, Cardiovascular Medicine, Brigham and Women's Hospital, Associate Professor, Harvard Medical School There are a number of practical challenges that must be …

MGH Division of Clinical Research

Welcome to the Genetic Code: An Overview of Basic Genetics

This introductory course will review fundamental language and concepts including DNA anatomy and genome organization; genotype-phenotype correlations; basic population genetics; and genotyping. Participants will have the opportunity to submit questions to the faculty prior to the lectures. This course is …