MGH Division of Clinical Research

A Practical Introduction to Statistical Genetics: Genome-Wide Association Studies (II)

Ended: Sept. 16, 2020

Topics: association analysis (regression, effect size and odds ratio, hypothesis testing, type I and type II errors); visualization and diagnosis (Manhattan plot, LocusZoom, population stratification, spurious association); GWAS summary statistics; meta-analysis; functional annotation and gene-set/pathway analysis; introduction to mixed effects modeling

Speaker: Chia-Yen Chen

Program:
A Practical Introduction to Statistical Genetics

Category:
Genomics

Sponsor:
MGH Division of Clinical Research

Sessions

Genome-wide association studies (II) Sept. 16, 2020 09/16/20
9:30AM-11AM 		9:30 AM – 11 AM
STRATUS Online Moodle, None

Other Offerings

Past Offerings
A Practical Introduction to Statistical Genetics: Genome-Wide Association Studies (II) Genome-wide association studies (II) Sept. 18, 2019 09/18/19

Reviews

Anonymous:
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Date Reviewed: Sept. 18, 2020, 3:01 p.m.
Zhaozhi L:
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Date Attended: Sept. 18, 2020, 7:31 a.m.
Date Reviewed: Sept. 18, 2020, 11:31 a.m.
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Date Reviewed: Sept. 18, 2020, 8:26 a.m.
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Date Reviewed: Sept. 18, 2020, 7:24 a.m.
Eunpyo H:
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Date Attended: Sept. 18, 2020, 7:22 a.m.
Date Reviewed: Sept. 16, 2020, 7:30 a.m.
Anonymous:
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Date Reviewed: Sept. 18, 2019, 6:39 p.m.
Anonymous: Very thorough and understandable introduction to imputation, as well as meta-analysis as used in GWAS. Analysis section was a review of basic statistics which may have been better placed in a different course - for GWAS lecture, could focus on the common reporting of associations (ORs, p values, standard error) and some unique features of this in genetics (e.g. how to adjust for multiple testing). Overall, though, a very helpful lecture.
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Date Reviewed: Sept. 18, 2019, 11:13 a.m.
Ying Z:
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Date Attended: Sept. 18, 2019, 11:09 a.m.
Date Reviewed: Sept. 18, 2019, 11:12 a.m.
Anonymous:
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Date Reviewed: Sept. 18, 2019, 9:39 a.m.