MGH Division of Clinical Research

A Practical Introduction to Statistical Genetics: Mendelian Randomization (MR)

Ended: Oct. 23, 2019

Topics: causal effects and graphical representation; instrumental variables; basic ideas, advantages, assumptions and caveats of MR; two-stage least square method for MR; ratio of coefficient method for MR; MR using multiple SNPs; MR using GWAS summary statistics; two-sample MR; detecting and controlling for pleiotropic bias; introduction to multivariable MR and phenome-wide approaches

Speaker: Chia-Yen Chen

Program:
A Practical Introduction to Statistical Genetics

Category:
Genomics

Sponsor:
MGH Division of Clinical Research

Sessions

Oct. 23, 2019 10/23/19
8:30AM-10AM 		8:30 AM – 10 AM
Garrod/Mendel, Floor 2, Simches Research Center

Other Offerings

Past Offerings
A Practical Introduction to Statistical Genetics: Mendelian Randomization (MR) Oct. 14, 2020 10/14/20

Reviews

Michael S:
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Date Attended: Oct. 14, 2020, 10:24 a.m.
Date Reviewed: Oct. 19, 2020, 4:04 p.m.
Anonymous:
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Date Reviewed: Oct. 14, 2020, 11:18 a.m.
Anonymous: Thanks for your hard work.
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Date Reviewed: Oct. 14, 2020, 11:06 a.m.
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Date Reviewed: Oct. 14, 2020, 10:49 a.m.
Anonymous: Great class. I could watch it several times.
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Date Reviewed: Oct. 14, 2020, 10:42 a.m.
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Date Reviewed: Oct. 26, 2019, 10:55 p.m.
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Date Reviewed: Oct. 25, 2019, 8:43 a.m.
Anonymous: Definitely helpful and informative lecture. But I think maybe a short break during the lecture will be beneficial.I got a little tired during the second half. Besides, if practical, I think it’s a good idea to give us some relevant papers in advance before each lecture so we are more familiar with the topic.
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Date Reviewed: Oct. 24, 2019, 1:14 p.m.
Anonymous: While still a helpful introductory lecture, this one was more confusing than some of the previous lectures. It would be helpful to spend more time on background (why this is needed, how it was done before or is done in other study types). An idea of practical examples early on might make it more clear why this technique is used.
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Date Reviewed: Oct. 24, 2019, 12:24 p.m.
Anonymous:
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Date Reviewed: Oct. 23, 2019, 1:42 p.m.